Associations between obesity, smoking and lymph node status at breast cancer diagnosis in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

ABSTRACT:

Introduction

There is evidence suggesting that smoking and obesity prior to a breast cancer diagnosis is associated with poorer outcomes. In this study, we investigate the associations between smoking and obesity prior to a breast cancer diagnosis and the presence of lymph node metastases at diagnosis.

Methods

Women with stage I-III breast cancer (n = 3,304) were identified from the National Cancer Institute's Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Univariable and multivariable log-binomial models were used to estimate relative risks (RR) and 95% confidence intervals (CIs) for associations between lymph node positive breast cancer and; i) smoking, and ii) obesity prior to diagnosis.

Results

Pre-diagnostic smoking/obesity was not associated with

SUBMITTER: Smith A 

PROVIDER: S-EPMC6114724 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature