Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC6118321 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20180809 8
The US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) is an important source for detecting adverse drug event (ADE) signals. In this article, we propose a three-component mixture model (3CMM) for FAERS signal detection. In 3CMM, a drug-ADE pair is assumed to have either a zero relative risk (RR), or a background RR (mean RR = 1), or an increased RR (mean RR >1). By clearly defining the second component (mean RR = 1) as the null distribution, 3CMM estimates local false ...[more]