Role of nuclear factor ?B in multiple sclerosis and experimental autoimmune encephalomyelitis.

ABSTRACT: The transcription factor nuclear factor ?B (NF-?B) plays major roles in inflammatory diseases through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). It has been shown that NF-?B is activated in multiple cell types in the CNS of MS patients, including T cells, microglia/macrophages, astrocytes, oligodendrocytes, and neurons. Interestingly, data from animal model studies, particularly studies of experimental autoimmune encephalomyelitis, have suggested that NF-?B activation in these individual cell types has distinct effects on the development of MS. In this review, we will cover the current literature on NF-?B and the evidence for its role in the development of MS and its animal model experimental autoimmune encephalomyelitis.

SUBMITTER: Yue Y 

PROVIDER: S-EPMC6126134 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature