Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice.

ABSTRACT:

Background

Persistent hepatitis B virus (HBV) infection causes liver cirrhosis and hepatocellular carcinoma and constitutes a major worldwide health problem. Currently, anti-HBV drugs are limited to peginterferon and nucleos(t)ide analogs, which are costly and have considerable side effects; the development of novel, effective anti-HBV agents is crucial.

Methods

Catechins are a major group of compounds found in green tea extract and epigallocatechin gallate (EGCG) has been shown to have antiviral properties, including inhibition of cellular entry by HBV. FRG (Fah^-/-/ Rag2^-/-/ IL-2Rγ^/-) mice were used in this study to generate chimeras carrying human primary hepatocytes, to facilitate investigation of the inhibitory effect of EGCG on HBV infec

SUBMITTER: Lai YH 

PROVIDER: S-EPMC6127945 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature