Ontology highlight
ABSTRACT:
SUBMITTER: Nassrallah A
PROVIDER: S-EPMC6128693 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
eLife 20180907
DE-ETIOLATED 1 (DET1) is an evolutionarily conserved component of the ubiquitination machinery that mediates the destabilization of key regulators of cell differentiation and proliferation in multicellular organisms. In this study, we provide evidence from Arabidopsis that DET1 is essential for the regulation of histone H2B monoubiquitination (H2Bub) over most genes by controlling the stability of a deubiquitination module (DUBm). In contrast with yeast and metazoan DUB modules that are associat ...[more]