Ontology highlight
ABSTRACT:
SUBMITTER: Palin K
PROVIDER: S-EPMC6131244 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180910 1
Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cancers, 256 of which have been whole-genome sequenced (WGSed). The imbalances pinpoint 38 genes as plausible AI targets based on previous knowledge. Unbiased CRISPR-Cas9 knockout and activation screens identified in total 79 genes within AI peaks regulat ...[more]