A novel mathematical method for disclosing oscillations in gene transcription: A comparative study.

ABSTRACT: Circadian rhythmicity, the 24-hour cycle responsive to light and dark, is determined by periodic oscillations in gene transcription. This phenomenon has broad ramifications in physiologic function. Recent work has disclosed more cycles in gene transcription, and to the uncovering of these we apply a novel signal processing methodology known as the pencil method and compare it to conventional parametric, nonparametric, and statistical methods.

Methods

In order to assess periodicity of gene expression over time, we analyzed a database derived from livers of mice entrained to a 12-hour light/12-hour dark cycle. We also analyzed artificially generated signals to identify differences between the pencil decomposition and other alternative methods.

Results

The pencil decomposition r

SUBMITTER: Antoulas AC 

PROVIDER: S-EPMC6145530 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature