Ontology highlight
ABSTRACT:
SUBMITTER: Alvelos MI
PROVIDER: S-EPMC6148369 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Diabetes, obesity & metabolism 20180901
Pancreatic β-cell dysfunction and death are determinant events in type 1 diabetes (T1D), but the molecular mechanisms behind β-cell fate remain poorly understood. Alternative splicing is a post-transcriptional mechanism by which a single gene generates different mRNA and protein isoforms, expanding the transcriptome complexity and enhancing protein diversity. Neuron-specific and certain serine/arginine-rich RNA binding proteins (RBP) are enriched in β-cells, playing crucial roles in the regulati ...[more]