Dataset Information

Primary cardiac angiosarcoma. Histopathology imaging correlation.

ABSTRACT: We report a novel observation of a cardiac hemangioma possible transformation into cardiac angiosarcoma. This report should give a new insight on the pathogenesis of the tumor, always thought to have a de-novo genesis. We emphasize in our report the value of combining imaging modalities to examine the anatomic and metabolic properties of cardiac tumors providing a valuable tool for comprehensive assessment. <Learning objective: Assessment of cardiac tumors should combine different imaging modalities to examine the anatomic and metabolic properties of the lesions. We report a novel observation on cardiac angiosarcoma possible transformation from a cardiac hemangioma. This report should give a new insight into the pathogenesis of the tumor, always thought to have a de-novo genesis.>.

SUBMITTER: Elsheshtawy M

PROVIDER: S-EPMC6149278 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Primary cardiac angiosarcoma. Histopathology imaging correlation.

Elsheshtawy Moustafa M Virparia Vasudev V Pulumati Krishna Anuraag KA Chaudhury Samiran Roy SR Prabhu Sudhakar S Khanna Ashok A

Journal of cardiology cases 20170722 4

We report a novel observation of a cardiac hemangioma possible transformation into cardiac angiosarcoma. This report should give a new insight on the pathogenesis of the tumor, always thought to have a de-novo genesis. We emphasize in our report the value of combining imaging modalities to examine the anatomic and metabolic properties of cardiac tumors providing a valuable tool for comprehensive assessment. <<b>Learning objective:</b> Assessment of cardiac tumors should combine different imaging ...[more]

PMID: 30279812

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Project description:OBJECT:Glioblastoma is a highly malignant brain tumor, for which standard treatment consists of surgery, radiotherapy, and chemotherapy. Increasing extent of tumor resection (EOTR) is associated with prolonged survival. Intraoperative magnetic resonance imaging (iMRI) is used to increase EOTR, based on contrast enhanced MR images. The correlation between intraoperative contrast enhancement and tumor has not been studied systematically. METHODS:For this prospective cohort study, we recruited 10 patients with a supratentorial brain tumor suspect for a glioblastoma. After initial resection, a 0.15 Tesla iMRI scan was made and neuronavigation-guided biopsies were taken from the border of the resection cavity. Scores for gadolinium-based contrast enhancement on iMRI and for tissue characteristics in histological slides of the biopsies were used to calculate correlations (expressed in Kendall's tau). RESULTS:A total of 39 biopsy samples was available for further analysis. Contrast enhancement was significantly correlated with World Health Organization (WHO) grade (tau 0.50), vascular changes (tau 0.53), necrosis (tau 0.49), and increased cellularity (tau 0.26). Specificity of enhancement patterns scored as "thick linear" and "tumor-like" for detection of (high grade) tumor was 1, but decreased to circa 0.75 if "thin linear" enhancement was included. Sensitivity for both enhancement patterns varied around 0.39-0.48 and 0.61-0.70, respectively. CONCLUSIONS:Presence of intraoperative contrast enhancement is a good predictor for presence of tumor, but absence of contrast enhancement is a bad predictor for absence of tumor. The use of gadolinium-based contrast enhancement on iMRI to maximize glioblastoma resection should be evaluated against other methods to increase resection, like new contrast agents, other imaging modalities, and "functional neurooncology" - an approach to achieve surgical resection guided by functional rather than oncological-anatomical boundaries.

Dataset Information

Primary cardiac angiosarcoma. Histopathology imaging correlation.

Publications

Primary cardiac angiosarcoma. Histopathology imaging correlation.

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