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Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.

ABSTRACT: Although the pathogenesis of intestinal failure (IF)-associated liver disease (IFALD) is uncertain, IF-associated cholestasis mediated by the combination of intestinal injury and parenteral nutrition (PN) can lead to disturbed hepatocyte bile acids (BA) homeostasis and cause liver damages. We here show that neurotensin (NT; also known as NTS) concentrations were lower compared to healthy matched controls. Patients with cholestasis [56.1?ng/L (9.7-154.7) vs. 210.4?ng/L (134-400.4), p?

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC6154870 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.

Xiao Yongtao Y   Yan Weihui W   Lu Ying Y   Zhou Kejun K   Cai Wei W  

EBioMedicine 20180810

Although the pathogenesis of intestinal failure (IF)-associated liver disease (IFALD) is uncertain, IF-associated cholestasis mediated by the combination of intestinal injury and parenteral nutrition (PN) can lead to disturbed hepatocyte bile acids (BA) homeostasis and cause liver damages. We here show that neurotensin (NT; also known as NTS) concentrations were lower compared to healthy matched controls. Patients with cholestasis [56.1 ng/L (9.7-154.7) vs. 210.4 ng/L (134-400.4), p < .001] had  ...[more]

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