Lifetime cognition and late midlife blood metabolites: findings from a British birth cohort.

ABSTRACT: Maintenance of healthy cognitive ageing is vital for independence and wellbeing in the older general population. We investigated the association between blood metabolites and cognitive function and decline. Participants from the MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort) were studied; 233 nuclear magnetic resonance circulating metabolite measures were quantified in 909 men and women at ages 60-64. Short-term and delayed verbal memory and processing speed were concurrently assessed and these tests were repeated at age 69. Linear regression analyses tested associations between metabolites and cognitive function at ages 60-64, and changes in these measures by age 69, adjusting for childhood cognition, education, socio-economic status and lifestyle fact

SUBMITTER: Proitsi P 

PROVIDER: S-EPMC6158182 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature