Deglycosylation of wogonoside enhances its anticancer potential.

ABSTRACT:

Introduction

Scutellaria baicalensis is commonly used in Asia as an herbal medicine to treat a variety of ailments, including cancer. Wogonoside, one major constituent of S. baicalensis, can be primarily converted to wogonin through deglycosylation via enteric microbiome metabolism.

Materials and methods

The antiproliferative effects of the glycoside (wogonoside) and its deglycosylated compound (wogonin) on a panel of human cancer cell lines from the most common solid tumors were evaluated using the MTS colorimetric assay. Cell cycle and apoptosis were determined using flow cytometry. Enzymatic activities of caspases were measured, and the interactions of wogonin and caspases were explored by a docking analysis.

Results

Wogonoside did not have obvious antiproliferativ

SUBMITTER: Wang CZ 

PROVIDER: S-EPMC6159225 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature