Dataset Information
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Ontology highlight
ABSTRACT: Aim
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.Results
CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens.Conclusion
Caenorhabditis elegans is an efficient heterologous host to evaluate immunomodulatory compounds and identify components of the pathway(s) involved in the mode of action of compounds.
SUBMITTER: Coleman JJ
PROVIDER: S-EPMC6161127 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Future medicinal chemistry 20161014 17
<h4>Aim</h4>Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.<h4>Results</h4>CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ul ...[more]
