Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.

ABSTRACT:

Aim

Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.

Results

CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens.

Conclusion

Caenorhabditis elegans is an effici

SUBMITTER: Coleman JJ 

PROVIDER: S-EPMC6161127 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature