A prospective evaluation of plasma polyphenol levels and colon cancer risk.

ABSTRACT: Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (q_values ) was computed to control for multiple comparisons. All st

SUBMITTER: Murphy N 

PROVIDER: S-EPMC6175205 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature