Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration.

ABSTRACT: Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting their differentiation and angiogenic potential. Recent studies reported that specific abnormalities caused by the non-inherited disease are often retained in induced pluripotent stem cell (iPSC)-derived products obtained from patients. Thus, it is indispensable to first assess whether iPSCs derived from patients with CKD due to non-inherited disease (CKD-iPSCs) have the ability to generate kidneys. In this study, we generated iPSCs from patients undergoing haemodialysis due t

SUBMITTER: Tajiri S 

PROVIDER: S-EPMC6175865 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature