Free and Bioavailable 25-Hydroxyvitamin D Concentrations are Associated With Disease Activity in Pediatric Patients With Newly Diagnosed Treatment Naive Ulcerative Colitis.

ABSTRACT:

Background

Vitamin D regulates intestinal epithelial and immune functions, and vitamin D receptor deficiency increases the severity of murine colitis. Bioavailable 25-hydroxyvitamin D (25(OH)D) is available to target tissues and may be a driver of immune function. The aim is to evaluate the relationship of bioavailable 25(OH)D to the clinical expression of treatment naive pediatric ulcerative colitis (UC).

Methods

The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) study enrolled children ≤17 years newly diagnosed with UC. Free and total 25(OH)D were directly measured and 25(OH)D fractions were compared with disease activity measures.

Results

Data were available on 388 subjects, mean age 12.7 years, 49% female, 84% with extensive/pancolitis. Th

SUBMITTER: Sauer CG 

PROVIDER: S-EPMC6176888 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature