STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.

ABSTRACT: Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. We have previously shown that influenza induces type I interferon (IFN)-mediated inhibition of Type 17 immune responses, resulting in exacerbation of bacterial burden during influenza and Staphylococcus aureus super-infection. In this study, we investigated the role of STAT2 signaling during influenza and influenza-bacterial super-infection in mice. Influenza-infected STAT2^-/- mice had increased morbidity, viral burden, and inflammation when compared to wild-type mice. Despite an exaggerated inflammatory response to influenza infection, we found increased ba

SUBMITTER: Gopal R 

PROVIDER: S-EPMC6178135 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature