Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach.

ABSTRACT:

Objectives

The aim of this study was to evaluate the feasibility of targeted imaging of myocardial cannabinoid type 1 receptor (CB1-R) and its potential up-regulation in obese mice with translation to humans using [¹¹C]-OMAR and positron emission tomography (PET)/computed tomography (CT).

Background

Activation of myocardial CB1-R by endocannabinoids has been implicated in cardiac dysfunction in diabetic mice. Obesity may lead to an up-regulation of myocardial CB1-R, potentially providing a mechanistic link between obesity and the initiation and/or progression of cardiomyopathy.

Methods

Binding specificity of [¹¹C]-OMAR to CB1-R was investigated by blocking studies with rimonabant in mice. The heart was harvested from each mouse, and its radioacti

SUBMITTER: Valenta I 

PROVIDER: S-EPMC6178217 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature