Ontology highlight
ABSTRACT:
SUBMITTER: Leikina E
PROVIDER: S-EPMC6203449 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Developmental cell 20180906 6
Classic mechanisms for membrane fusion involve transmembrane proteins that assemble into complexes and dynamically alter their conformation to bend membranes, leading to mixing of membrane lipids (hemifusion) and fusion pore formation. Myomaker and Myomerger govern myoblast fusion and muscle formation but are structurally divergent from traditional fusogenic proteins. Here, we show that Myomaker and Myomerger independently mediate distinct steps in the fusion pathway, where Myomaker is involved ...[more]