Ontology highlight
ABSTRACT:
SUBMITTER: He Q
PROVIDER: S-EPMC6204122 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
He Qionger Q Arroyo Erica D ED Smukowski Samuel N SN Xu Jian J Piochon Claire C Savas Jeffrey N JN Portera-Cailliau Carlos C Contractor Anis A
Molecular psychiatry 20180427 11
Sensory perturbations in visual, auditory and tactile perception are core problems in fragile X syndrome (FXS). In the Fmr1 knockout mouse model of FXS, the maturation of synapses and circuits during critical period (CP) development in the somatosensory cortex is delayed, but it is unclear how this contributes to altered tactile sensory processing in the mature CNS. Here we demonstrate that inhibiting the juvenile chloride co-transporter NKCC1, which contributes to altered chloride homeostasis i ...[more]