Prenatal complications are associated with the postnatal airway host response and microbiota in intubated preterm infants.

ABSTRACT:

Purpose

To prospectively examine the relationship between prenatal events, postnatal airway host response and microbiota, and clinical outcomes.

Materials and methods

Tracheal aspirates collected at seven days of age from 71 mechanically ventilated infants (median gestational age (GA), 25 weeks [range 23-28]) were simultaneously processed for a 12-plex protein assay and bacterial identification by 16S rRNA sequencing. Phenotypes were determined by unsupervised clustering of the protein analytes. Subject characteristics, microbial communities and clinical factors and outcomes were compared across the phenotype groups.

Results

Three clusters were identified: 1 (high protein levels), 2 (high proinflammatory proteins and low anti-inflammatory proteins), and 3 (low protein

SUBMITTER: Wagner BD 

PROVIDER: S-EPMC6212338 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature