Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA.

ABSTRACT:

Background

Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance.

Methods

Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2^pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells.

Results

BST2^pos CH cells retained the capacity to (i) respond to injury signals ge

SUBMITTER: Lo Sicco C 

PROVIDER: S-EPMC6225669 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature