Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.

ABSTRACT:

Purpose

The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T₁ and T₂ mapping in DCE-MRI studies in mice.

Methods

The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively. In vitro and in vivo studies of mouse brain were performed to evaluate the accuracy of MRF measurements with both fully sampled and undersampled data. The application of MRF to dynamic T₁ and T₂ mapping in DCE-MRI studies were demonstrated in a mouse

SUBMITTER: Gu Y 

PROVIDER: S-EPMC6226386 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature