Ontology highlight
ABSTRACT:
SUBMITTER: Denaxa M
PROVIDER: S-EPMC6230259 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Denaxa Myrto M Neves Guilherme G Rabinowitz Adam A Kemlo Sarah S Liodis Petros P Burrone Juan J Pachnis Vassilis V
Cell reports 20180201 7
Cortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how the correct number of cortical interneurons (CIs) is established in the mammalian forebrain. CIs are generated in excess from basal forebrain progenitors, and their final numbers are adjusted via an intrinsically determined program of apoptosis that takes pla ...[more]