Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial: A Randomized Clinical Trial.

ABSTRACT:

Importance

CER-001 is a negatively charged, engineered pre-β high-density lipoprotein (HDL) mimetic containing apolipoprotein A-I and sphingomyelin. Preliminary studies demonstrated favorable effects of CER-001 on cholesterol efflux and vascular inflammation. A post hoc reanalysis of a previously completed study of intravenous infusion of CER-001, 3 mg/k, showed that the intravenous infusion in patients with a high coronary plaque burden promoted regression as assessed by intravascular ultrasonography.

Objective

To determine the effect of infusing CER-001 on coronary atherosclerosis progression in statin-treated patients.

Design, setting, and participants

A double-blind, randomized, multicenter trial evaluating the effect of 10 weekly intravenous infusions of CER-001,

SUBMITTER: Nicholls SJ 

PROVIDER: S-EPMC6233644 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature