Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites.

ABSTRACT: The eukaryotic epigenetic machinery can be modified by bacteria to reprogram the response of eukaryotes during their interaction with microorganisms. We discovered that the bacterium Streptomyces rapamycinicus triggered increased chromatin acetylation and thus activation of the silent secondary metabolism ors gene cluster in the fungus Aspergillus nidulans. Using this model, we aim understanding mechanisms of microbial communication based on bacteria-triggered chromatin modification. Using genome-wide ChIP-seq analysis of acetylated histone H3, we uncovered the unique chromatin landscape in A. nidulans upon co-cultivation with S. rapamycinicus and relate changes in the acetylation to that in the fungal transcriptome. Differentially acetylated histones wer

SUBMITTER: Fischer J 

PROVIDER: S-EPMC6234034 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature