Bioinformatics analysis of differentially expressed genes in rotator cuff tear patients using microarray data.

ABSTRACT:

Background

Rotator cuff tear (RCT) is a common shoulder disorder in the elderly. Muscle atrophy, denervation and fatty infiltration exert secondary injuries on torn rotator cuff muscles. It has been reported that satellite cells (SCs) play roles in pathogenic process and regenerative capacity of human RCT via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) of SCs that regulated between the torn supraspinatus (SSP) samples and intact subscapularis (SSC) samples, identify their functions and molecular pathways.

Methods

The gene expression profile GSE93661 was downloaded and bioinformatics analysis was made.

Results

Five hundred fifty one DEGs totally were identified. Among them, 272 DEGs were overexpressed, and the rem

SUBMITTER: Ren YM 

PROVIDER: S-EPMC6234628 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature