Association Between Subclinical Brain Infarcts and Functional Decline Trajectories.

ABSTRACT:

Objectives

To test associations between subclinical brain infarcts (SBIs) and functional decline independently of intervening clinical vascular events and other vascular risk factors.

Design

Longitudinal follow-up for a mean 7.3 years. Generalized estimating equation models were used to test associations between SBIs, number of perivascular spaces (PVSs), baseline Barthel Index (BI), and change in BI, adjusting for sociodemographic, vascular, and cognitive risk factors and for stroke and myocardial infarction occurring during follow-up.

Setting

Population-based prospective cohort study.

Participants

Stroke-free individuals from the racially and ethnically diverse Northern Manhattan Study (N=1,290).

Measurements

Annual functional assessments using the BI

SUBMITTER: Dhamoon MS 

PROVIDER: S-EPMC6235693 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature