Ontology highlight
ABSTRACT:
SUBMITTER: Ferretti MB
PROVIDER: S-EPMC6239892 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ferretti Max Berman MB Barre Jennifer Louise JL Karbstein Katrin K
Cell chemical biology 20180830 11
Consistent with its location on the ribosome, reporter assays demonstrate a role for Rps26 in recognition of the Kozak sequence. Consequently, Rps26-deficient ribosomes display preference for mRNAs encoding components of the high salt and high pH stress response pathways and accumulate in yeast exposed to high salt or pH. Here we use this information to reprogram the cellular response to high salt by introducing point mutations in the Kozak sequence of key regulators for the cell wall MAP-kinase ...[more]