Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.

ABSTRACT: We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m²) and 50% obese (BMI ≥ 30 kg/m²)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed significantly more dietary fiber, had greater microbial alpha-diversity, different beta-diversity, and had a greater concentration of total fecal SCFAs (p-value < 0.002). Lean Ghanaians had significantly greater network density, connectivity and stability than either obese Ghanaians, or lean and obese US participants (false discovery rate (FDR) corrected p-value ≤ 0.01). Bacteroides uniformis was significantly more abundant in lean women, irrespective of

SUBMITTER: Dugas LR 

PROVIDER: S-EPMC6244201 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature