Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia.

ABSTRACT:

Background

The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on physiological functions. We have previously investigated the potential pathophysiological relationship between IL-18 and dyslipidemia, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, which were mediated by lipid energy imbalance. Therefore, herein we focused on brown adipocytes (BAs) and brown adipose tissue (BAT) related to energy consumption as non-shivering thermogenesis.

Methods

Il18^-/- male mice were generated on the C57Bl/6 background, and littermate C57Bl/6 Il18^+/+ male mice were used as controls. To reveal the d

SUBMITTER: Yamanishi K 

PROVIDER: S-EPMC6245626 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature