Long-term outcomes following first short-term clinically important deterioration in COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by varying trajectories of decline. Information regarding the prognostic value of preventing short-term clinically important deterioration (CID) in lung function, health status, or first moderate/severe exacerbation as a composite endpoint of worsening is needed. We evaluated post hoc the link between early CID and long-term adverse outcomes.

Methods

CID was defined as ≥100 mL decrease in forced expiratory volume in 1 s (FEV₁), ≥4-unit increase in St George's Respiratory Questionnaire (SGRQ) score from baseline, and/or a moderate/severe exacerbation during enrollment in two 3-year studies. Presence of CID was assessed at 6 months for the principal analysis (TORCH) and 12 months for the confir

SUBMITTER: Naya IP 

PROVIDER: S-EPMC6245880 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature