Metabolomics approach in the investigation of depression biomarkers in pharmacologically induced immune-related depression.

ABSTRACT:

Background

The aim of this study was to identify previously unrecognised biological pathways and biomarkers that might expand the inflammatory hypothesis of depression.

Methods

Broad metabolomics analyses in plasma samples from 31 chronic hepatitis C-infected patients with and without immune-related depression were carried out using the Absolute IDQ p180 kit-a targeted metabolomics approach of combined direct flow injection and liquid chromatography that measures acylcarnitines, amino acids, biogenic amines, glycerophospholipids, sphingolipids, and sugars.

Results

The measurements showed that the average concentration of the branched-chain amino acid isoleucine was significantly lower in depressive HCV patients in comparison to non-depressive HCV patients [depression

SUBMITTER: Baranyi A 

PROVIDER: S-EPMC6264814 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature