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Further mulinane and azorellane diterpenoids isolated from Mulinum crassifolium and Azorella compacta.

ABSTRACT: The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1-2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods.

SUBMITTER: Borquez J

PROVIDER: S-EPMC6271538 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Further mulinane and azorellane diterpenoids isolated from Mulinum crassifolium and Azorella compacta.

Bórquez Jorge J Ardiles Alejandro A Loyola Luis Alberto LA Peña-Rodriguez Luis Manuel LM Molina-Salinas Gloria María GM Vallejos Javier J Collado Isidro G IG Simirgiotis Mario J MJ

Molecules (Basel, Switzerland) 20140328 4

The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1-2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and comp ...[more]

PMID: 24686578

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