Ontology highlight
ABSTRACT:
SUBMITTER: Beumer J
PROVIDER: S-EPMC6276989 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Beumer Joep J Artegiani Benedetta B Post Yorick Y Reimann Frank F Gribble Fiona F Nguyen Thuc Nghi TN Zeng Hongkui H Van den Born Maaike M Van Es Johan H JH Clevers Hans H
Nature cell biology 20180723 8
Enteroendocrine cells (EECs) control a wide range of physiological processes linked to metabolism<sup>1</sup>. We show that EEC hormones are differentially expressed between crypts (for example, Glp1) and villi (for example, secretin). As demonstrated by single-cell mRNA sequencing using murine Lgr5<sup>+</sup> cell-derived organoids, BMP4 signals alter the hormone expression profiles of individual EECs to resemble those found in the villus. Accordingly, BMP4 induces hormone switching of EECs mi ...[more]