FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation.

ABSTRACT: Canonical Wnt/β-catenin signaling is an essential regulator of various cellular functions throughout development and adulthood. Aberrant Wnt/β-catenin signaling also contributes to various pathologies including cancer, necessitating an understanding of cell context-dependent mechanisms regulating this pathway. Since protein-protein interactions underpin β-catenin function and localization, we sought to identify novel β-catenin interacting partners by affinity purification coupled with tandem mass spectrometry in vascular smooth muscle cells (VSMCs), where β-catenin is involved in both physiological and pathological control of cell proliferation. Here, we report novel components of the VSMC β-catenin interactome. Bioinformatic analysis of the protein networks implies potentially novel funct

SUBMITTER: Ehyai S 

PROVIDER: S-EPMC6280795 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature