Effect of magnesium on cognition after aneurysmal subarachnoid haemorrhage in a randomized trial.

ABSTRACT:

Background and purpose

In randomized trials magnesium supplementation did not improve clinical outcome after aneurysmal subarachnoid haemorrhage (aSAH) on handicap scales. After aSAH, many patients have cognitive problems that may not translate into handicap. The effect of magnesium on cognitive outcome after aSAH was studied.

Methods

In total, 209 patients who had been included in the Magnesium for Aneurysmal Subarachnoid Haemorrhage (MASH-2) trial in the University Medical Centre of Utrecht were studied. Patients had been randomized to 64 mmol magnesium sulfate daily or placebo during hospitalization. Three months after aSAH patients underwent a neuropsychological examination (NPE) consisting of six neuropsychological tests or a brief cognitive assessment. Poisson and line

SUBMITTER: Huenges Wajer IMC 

PROVIDER: S-EPMC6282849 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature