Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria.

ABSTRACT: Mitochondrial electron transport chain (ETC) plays a central role in ATP synthesis, and its dysfunction is associated with human diseases. Recent studies revealed that individual ETC complexes are assembled into supercomplexes. The main supercomplex, respirasome composed of complexes I, III, and IV has been suggested to improve electron channeling and control ROS production, maintain the structural integrity of ETC complexes and prevent protein aggregation in the inner mitochondrial membrane. However, many questions related to the structural organization of the respirasome, particularly, a possible role of complexes I and II in respirasome formation remain unclear. Here, we investigated whether genetic and pharmacological inhibition of complexes I and II affect respirasome assembly in card

SUBMITTER: Jang S 

PROVIDER: S-EPMC6286307 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature