T_peak-T_end, T_peak-T_end/QT ratio and T_peak-T_end dispersion for risk stratification in Brugada Syndrome: A systematic review and meta-analysis.

ABSTRACT:

Background

Brugada syndrome is an ion channelopathy that predisposes affected subjects to ventricular tachycardia/fibrillation (VT/VF), potentially leading to sudden cardiac death (SCD). T_peak-T_end intervals, (T_peak-T_end)/QT ratio and T_peak-T_end dispersion have been proposed for risk stratification, but their predictive values in Brugada syndrome have been challenged recently.

Methods

A systematic review and meta-analysis was conducted to examine their values in predicting arrhythmic and mortality outcomes in Brugada Syndrome. PubMed and Embase databases were searched until 1 May 2018, identifying 29 and 57 studies.

Results

Nine studies involving 1740 subjects (mean age 45 years old, 80% male, mean foll

SUBMITTER: Tse G 

PROVIDER: S-EPMC6288557 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature