Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation.

ABSTRACT:

Background

Faecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success is typically attributed to the restoration of a diverse microbiota. Viruses (including bacteriophages) are the most numerically dominant and potentially the most diverse members of the microbiota, but their fate following FMT has not been well studied.

Results

We studied viral transfer following FMT from 3 donors to 14 patients. Recipient viromes resembled those of their donors for up to 12 months. Tracking individual bacteriophage colonisation revealed that engraftment of individual bacteriophages was dependent on specific donor-recipient pairings. Specifically, multiple recipients from a single donor displayed highly individualised virus col

SUBMITTER: Draper LA 

PROVIDER: S-EPMC6288847 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature