Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction.

ABSTRACT:

Background

Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy for AKI is an unmet clinical need, and molecular mechanisms underlying the interactions between an injured kidney and distant organs remain unclear. Therefore, novel therapeutic strategies should be developed.

Methods

We directed the differentiation of human induced pluripotent stem (iPS) cells into endothelial progenitor cells (iEPCs), which were then applied for treating mouse AKI. The mouse model of AKI was induced by I/R injury.

Results

We discovered that intravenously infused iEPCs were recruited to the injured kidney, expressed the mature endotheli

SUBMITTER: Shen WC 

PROVIDER: S-EPMC6288873 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature