Ontology highlight
ABSTRACT:
SUBMITTER: Abaci HE
PROVIDER: S-EPMC6294003 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Abaci Hasan Erbil HE Coffman Abigail A Doucet Yanne Y Chen James J Jacków Joanna J Wang Etienne E Guo Zongyou Z Shin Jung U JU Jahoda Colin A CA Christiano Angela M AM
Nature communications 20181213 1
Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs), into HSCs remains a major challenge. Here, we demonstrate a biomimetic approach for generation of human HFs within HSCs by recapitulating the physiological 3D organization of cells in the HF microenvironment using 3D-printed ...[more]