The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.

ABSTRACT: γδ T cells that produce the cytokine IL-17 (Tγδ17 cells) are innate-like mediators of immunity that undergo effector programming in the thymus. While regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a commitment factor essential to all Tγδ17 cells has remained undefined. In this study, we identified the transcription factor c-Maf as a universal regulator of Tγδ17 cell differentiation and maintenance. Maf deficiency caused an absolute lineage block at the immature CD24⁺CD45RB^lo γδ thymocyte stage, which revealed a critical checkpoint in the acquisition of effector functions. Here, c-Maf enforced Tγδ17 cell identity by promoting chromatin accessibility and expression of key type 17 program genes, notably Rorc and Blk, while antagonizing the

SUBMITTER: Zuberbuehler MK 

PROVIDER: S-EPMC6294311 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature