Regular aspirin use and gene expression profiles in prostate cancer patients.

ABSTRACT:

Purpose

Pharmacoepidemiology studies suggest prognostic benefits of aspirin in prostate cancer. We hypothesized that aspirin induces transcriptional changes in tumors or normal prostate tissue.

Methods

We analyzed the prostatic transcriptome from men diagnosed with prostate cancer during follow-up of the Physicians' Health Study 1 (PHS, n = 149), initially a randomized controlled trial of aspirin. Aspirin target genes were identified through systematic literature review and a drug target database. We compared target gene expression according to regular aspirin use at cancer diagnosis and used whole-transcriptome gene set enrichment analysis to identify gene sets associated with aspirin use. Results were validated in the Health Professionals Follow-up Study (HPFS, n = 254) an

SUBMITTER: Stopsack KH 

PROVIDER: S-EPMC6298857 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature