Regular Aspirin Use and Mortality in Patients with Multiple Myeloma.

ABSTRACT:

Background

Inflammation is important in multiple myeloma pathogenesis, and regular aspirin use has been shown to confer a reduced risk of multiple myeloma. The influence of aspirin on survival after multiple myeloma diagnosis is unknown.

Methods

We identified 436 men and women diagnosed with multiple myeloma between 1980 and 2016 in the Health Professionals Follow-up Study and the Nurses' Health Study who reported aspirin intake biennially on follow-up questionnaires. Using multivariable Cox proportional hazards regression models, we estimated HRs and 95% confidence intervals (CI) associated with the effect of aspirin use on multiple myeloma-specific and overall mortality.

Results

Compared with nonusers, participants who used aspirin after diagnosis had a multivariabl

SUBMITTER: Marinac CR 

PROVIDER: S-EPMC8825752 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature