CD39⁺ regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function.

ABSTRACT: Increasing knowledge of the function and regulation of tumor-infiltrating lymphocytes has led to new insights in cancer immunotherapy. Regulatory T cells (Treg) accumulate in colon tumors, and we recently showed that CD39⁺ Treg from cancer patients inhibit transendothelial migration of conventional T cells. CD39 mediates the hydrolysis of ATP to immunosuppressive adenosine and adds to the immunosuppressive effects of Treg. Here, we further investigated the regulatory features of intratumoral CD39⁺ Treg in colon cancer. Using flow cytometry analyses of cells from 46 colon cancer patients, we confirm the accumulation of CD39⁺ Treg in the tumor tissue compared to unaffected colon tissue, and also show that tumor-infiltrating Treg express more CD39 and Foxp3 on

SUBMITTER: Ahlmanner F 

PROVIDER: S-EPMC6319332 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature