Ontology highlight
ABSTRACT:
SUBMITTER: Xiao X
PROVIDER: S-EPMC6323118 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Xiao Xiong X Lai Weifeng W Xie Huangfan H Liu Yang Y Guo Weijie W Liu Yifang Y Li Yu Y Li Yuanjun Y Zhang Jingliang J Chen Wenhan W Shi Minhui M Shang Lijun L Yin Ming M Wang Chengyan C Deng Hongkui H
Cell discovery 20190108
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the in vitro expansion of HSCs remains a challenge due to incomplete understanding of the signaling networks underlying HSC self-renewal. Here, we show that culturing human cord blood (CB) CD34<sup>+</sup> cells with JNK-IN-8, an inhibitor of the JNK signaling pathway, can enhance the self-renewal of HSCs with a 3.88-fold increase in cell number ...[more]