Endothelial cells from different anatomical origin have distinct responses during SNAIL/TGF-β2-mediated endothelial-mesenchymal transition.

ABSTRACT:

Background

Endothelial-mesenchymal transition (EndMT) is a complex process whereby differentiated endothelial cells undergo phenotypic transition to mesenchymal cells. EndMT can be stimulated by several factors and the most common are the transforming growth factor-beta (TGF-β) and SNAIL transcription factor. Given the diversity of the vascular system, it is unclear whether endothelial cells lining different vessels are able to undergo EndMT through the same mechanisms. Here we evaluate the molecular and functional changes that occur in different types of endothelial cells following induction of EndMT by overexpression of SNAIL and TGF-β2.

Results

We found that responses to induction by SNAIL are determined by cell origin and marker expression. Human coronary endothelial cel

SUBMITTER: Pinto MT 

PROVIDER: S-EPMC6325528 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature