Dataset Information

Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study.

ABSTRACT:

Background

Although retinol binding protein 4 (RBP4) has been implicated in insulin resistance in experimental studies, the association between RBP4 and risk of type 2 diabetes remains unclear. We assessed this association in a Chinese population, and pooled our results with those from two prior studies.

Methods

Plasma RBP4 levels were measured among 571 incident type 2 diabetes cases and 571 controls nested within the Singapore Chinese Health Study. All participants were free of diabetes, cancer and cardiovascular disease at blood collection (1999-2004). Incident cases of physician-diagnosed diabetes were self-reported at subsequent interviews (2006-2010).

Results

Plasma RBP4 levels were significantly higher in men than women, and the respective median values were 30 (interquartile range: 24-35) μg/mL and 25 (interquartile range: 21-31) μg/mL, respectively. With adjustment for diabetes risk factors, compared to the lowest quartile, the odds ratio (OR) and confidence interval (CI) for risk of type 2 diabetes associated with the highest quartile of RBP4 levels were 1.23 (0.73-2.07; P-trend = 0.14) in all subjects, 0.63 (0.27-1.45; P-trend = 0.65) in men, and 2.29 (1.05-5.00; P-trend = 0.018) in women. The difference in the risk estimates between men and women was statistically significant (P-interaction = 0.032). When we pooled our results with two prior studies, ORs (95% CIs) comparing high versus low category of RBP4 was 1.01 (0.70-1.46; I ² = 8.2%; P-heterogeneity = 0.34) in men, and 1.73 (1.28-2.33; I ² = 0%; P-heterogeneity = 0.80) in women.

Conclusions

Increased plasma RBP4 levels were associated with higher risk of type 2 diabetes in women but not in men.

SUBMITTER: Wang Y

PROVIDER: S-EPMC6329092 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study.

Wang Yeli Y Sun Liang L Lin Xu X Yuan Jian-Min JM Koh Woon-Puay WP Pan An A

Nutrition & metabolism 20190110

<h4>Background</h4>Although retinol binding protein 4 (RBP4) has been implicated in insulin resistance in experimental studies, the association between RBP4 and risk of type 2 diabetes remains unclear. We assessed this association in a Chinese population, and pooled our results with those from two prior studies.<h4>Methods</h4>Plasma RBP4 levels were measured among 571 incident type 2 diabetes cases and 571 controls nested within the Singapore Chinese Health Study. All participants were free of ...[more]

PMID: 30651745

Similar Datasets

Project description:BackgroundSince several lines of evidence suggest that estrogens may be involved in lung carcinogenesis, it has been hypothesized that intake of phytoestrogens, similar in molecular structure to mammalian estrogens, may be associated with lung cancer development.ObjectiveThe aim was to prospectively evaluate the association between phytoestrogen exposure and lung cancer risk in never-smoking women.MethodsWe conducted a nested case-control study within a population-based prospective cohort study of women. A total of 478 incident lung cancer cases and their individually matched controls were identified among never-smoking women after a mean follow-up of 15.6 years. Habitual intake of and internal exposure to phytoestrogens were assessed by repeated dietary surveys and urinary biomarkers, respectively. ORs and 95% CIs for lung cancer were estimated in conditional logistic regression models.ResultsAfter adjustment for potential confounders, a moderate intake of dietary isoflavones was inversely associated with lung cancer risk in never-smoking women, with the OR for the second quartile vs. the lowest quartile of intake being 0.52 (95% CI: 0.35, 0.76). Further increasing intake did not convey additional benefits, with ORs (95% CI) for the third and fourth quartiles of 0.53 (0.36, 0.78) and 0.47 (0.31, 0.72), respectively (P-overall < 0.001 and P-nonlinearity = 0.006). A similar association was seen when exposure to isoflavones was assessed by urinary biomarkers. ORs (95% CI) for the second, third, and fourth quartiles compared with the lowest quartile of urinary isoflavone excretion were 0.57 (0.39, 0.83), 0.64 (0.44, 0.92), and 0.60 (0.41, 0.86), respectively. The inverse association reached a plateau beyond the second quartile, with P-overall = 0.04 and P-nonlinearity = 0.15. Urinary excretion of gut-microbiota-derived metabolites of lignans was not related to lung cancer risk.ConclusionsThis study suggests that moderately increasing intake of isoflavone-rich foods is associated with lower risk of lung cancer in never-smoking women.

Dataset Information

Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study.

Background

Methods

Results

Conclusions

Publications

Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets