Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option critical limb ischemia.

ABSTRACT:

Background

Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach are inconsistent among different clinical trials. The purpose of this study was to identify the prognostic factors of responders and develop a predictive nomogram to guide patient selection.

Methods

We retrospectively reviewed a consecutive NO-CLI cohort who received peripheral blood-derived transplantation in our center. The patients who survived and achieved complete remission of CLI at 6 months post-transplantation were defined as responders. Logistic regression models were used to screen and identify the prognostic factors based on which predictive nomogra

SUBMITTER: Pan T 

PROVIDER: S-EPMC6329149 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature